411.12 600.48 l
BT
0 g
151.08 231.36 l
142.2 315 l
254.52 554.52 l
326.04 443.28 m
341.28 541.92 l
438.12 601.8 l
232.56 246.72 l
14.04 0 0 14.04 96.24 667.08 Tm
f*
380.76 409.68 l
355.08 168.96 m
/F6 1 Tf
f*
374.4 288.72 l
339 300.6 2.52 -0.06 re
1 g
The author presents a basic introduction to the world of genetic engineering. 407.04 415.32 0.36 -0.06 re
411.6 181.68 l
450.36 555.36 l
150.6 542.4 l
219.96 625.32 l
f*
W n
284.64 603.96 l
497.52 245.76 l
0 g
404.16 303.72 0.72 -0.06 re
331.68 572.88 0.36 -0.06 re
f*
f*
0 G
236.16 561 l
283.2 571.92 0.36 -0.06 re
q
14.4 225.36 582.48 -5.4 re
f*
f*
342.36 565.68 l
174.12 429.72 l
S
356.64 228.96 1.56 -0.06 re
170.88 473.52 l
450.96 459.6 l
164.28 436.68 l
14.4 273.48 582.48 -5.4 re
137.04 545.28 l
203.28 580.8 l
395.28 444.24 l
266.64 525.72 l
209.04 453.36 l
561.6 753.6 l
224.16 561.12 l
1 i 1 J 1 j 0.96 w 10 M []0 d
147.48 416.64 l
158.64 553.08 l
469.2 439.32 l
272.16 219.12 l
178.92 204.6 l
Q
158.16 301.92 l
232.56 580.68 m
355.56 204.48 m
177.48 558.36 l
f*
181.92 189.96 l
f*
177.48 219.6 l
101.28 233.4 l
331.8 238.08 l
158.16 667.44 l
0.047 0.169 0.506 rg
396.96 550.56 l
0.001 Tc
164.76 447.12 l
225 560.52 l
269.679 594.24 273.12 590.799 273.12 586.56 c
0 G
165.24 644.88 l
177.48 205.08 l
330.48 620.64 l
137.64 447 l
157.56 551.16 l
158.16 240.24 l
-14.5 -1.08 TD
539.88 313.453 527.147 300.72 511.44 300.72 c
410.64 228.72 l
177.48 119.28 m
f*
185.76 403.2 l
329.76 147 l
237.36 535.68 l
380.64 204.48 l
252.36 342.12 m
f*
113.4 301.8 0.48 -0.06 re
183.48 491.4 l
256.08 610.44 m
f*
f*
S
430.8 540.84 l
452.28 294.84 l
1 g
f*
377.52 216.36 m
f*
W n
204.24 566.16 l
462.96 506.28 l
Q
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f*
353.16 360.96 l
348.36 409.56 l
385.68 407.76 m
291.12 535.92 6 -5.4 re
349.68 360.96 l
ET
384.48 441.12 0.6 -0.06 re
303.6 477.96 l
f*
183.48 179.28 l
f*
304.56 241.56 m
181.92 189.96 m
181.92 566.16 m
152.88 133.68 l
369.12 166.68 m
1 g
278.52 156.6 m
455.88 464.16 l
360.36 498.96 m
240.72 639.48 l
0 g
187.56 355.2 l
397.8 572.4 0.48 -0.06 re
354.36 281.16 l
W n
236.16 552.84 l
0000312374 00000 n
455.76 417 l
165.96 125.52 l
275.52 265.44 l
5.88 0 0 5.88 433.08 580.2 Tm
310.08 623.28 l
0 g
q
0 G
443.64 580.56 l
f*
120.96 289.32 m
266.28 132.48 l
437.88 391.56 l
181.92 580.68 m
167.88 267 m
S
154.56 409.56 l
131.64 547.68 m
f*
318.24 264.36 l
140.76 264.72 l
207.12 410.16 l
f*
329.76 531 l
377.52 278.4 l
178.92 189.96 l
S
214.32 566.773 214.428 566.88 214.56 566.88 c
1 g
419.64 594.72 m
380.16 289.44 l
257.76 580.68 l
486.84 660.6 l
419.88 234.24 l
(Y chromosome)Tj
347.52 563.28 m
f*
14.4 207.36 582.48 -5.4 re
386.28 552.6 l
406.92 415.2 0.48 -0.06 re
317.16 621.24 l
S
418.32 596.76 l
0 Tr
438.12 168.48 l
234.12 231.36 l
730.56 638.52 l
224.64 439.44 l
320.76 407.64 l
153.12 229.8 l
498.24 394.68 0.96 -0.06 re
0 g
271.8 243.12 l
495.72 279.24 l
448.08 561.96 l
390.96 566.52 m
1 g
S
477.24 234.24 l
257.76 386.52 l
910.32 270.12 l
W n
383.28 299.64 l
157.08 551.4 l
366.72 626.52 l
153.96 412.56 l
373.32 413.04 1.8 -0.06 re
409.92 411.96 l
333.24 439.92 l
251.76 299.64 l
258.72 151.8 l
403.8 551.16 l
423.48 601.56 l
278.52 132.96 l
f*
297 581.16 l
f*
120.96 289.32 l
207.6 567.12 l
398.16 435.72 l
445.08 271.92 m
f*
(\(or stop signals\) for which they code. W n
113.4 300.48 0.48 -0.06 re
309.72 624.36 l
202.8 628.8 m
163.92 556.44 l
309 241.56 l
f*
449.04 250.2 l
367.68 533.76 l
407.16 428.4 l
181.92 614.64 m
202.8 117.96 l
467.76 298.8 m
512.4 267.24 l
343.92 624.6 l
0.002 Tc
329.76 235.56 l
438 251.4 6 -2.28 re
494.694 288.96 501.36 282.348 501.36 274.2 c
f*
148.2 537.72 l
152.16 261.36 l
f*
q
234 218.16 l
164.16 482.88 7.08 -3.96 re
BT
215.4 648.96 l
416.64 256.2 l
445.56 535.56 l
f*
S
290.16 432.36 l
0.749 0.875 1 rg
177.48 542.64 l
S
410.04 580.68 l
125.64 409.68 l
f*
234.24 477.24 m
309.72 618.24 l
272.16 635.16 l
257.76 311.16 l
256.8 574.32 0.48 -0.06 re
0.039 0.145 0.431 rg
234 602.76 l
0 g
177.48 106.08 l
326.64 267.24 l
215.4 276.96 l
344.28 571.68 0.36 -0.06 re
155.52 231.84 l
305.64 574.08 0.6 -0.06 re
f*
284.64 132.96 l
0 g
188.64 306.48 l
410.16 175.2 m
Q
444 600 l
5.88 0 0 5.88 181.2 260.88 Tm
257.76 285.24 l
294.24 526.68 l
f*
355.08 558.6 m
1 g
325.8 237.72 l
0.031 0.114 0.345 rg
214.08 302.28 0.6 -0.06 re
446.52 184.56 m
418.32 542.64 l
452.28 382.8 l
W n
249.12 271.8 l
214.399 445.2 214.56 445.039 214.56 444.84 c
309.96 152.4 l
504 266.16 l
f*
484.56 396.6 l
419.04 600.72 m
Q
170.88 683.64 l
0001347239 00000 n
137.512 600 145.2 592.366 145.2 582.96 c
322.56 436.68 l
W n
147.24 414.36 l
305.28 521.64 l
213.36 445.56 l
0 -1.072 TD
419.76 308.88 l
254.76 150.36 l
170.88 249.24 l
f*
14.4 513.36 582.48 -5.4 re
227.28 264.72 l
ET
329.4 244.68 l
411.24 546.36 l
215.4 205.08 l
169.983 265.2 165.36 269.823 165.36 275.52 c
416.16 297.36 l
f*
402.49 263.52 404.64 261.37 404.64 258.72 c
157.68 134.28 l
190.92 131.28 l
0 G
0 g
f*
263.16 480.12 m
264.72 267 l
/F6 1 Tf
246.6 606.24 l
f*
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321.6 580.68 l
392.88 539.88 l
f*
14.4 225.36 582.48 -5.4 re
35.64 757.08 540 -720 re
f*
f*
Q
398.16 445.56 l
170.4 189.72 l
300.96 548.16 l
0 g
224.76 298.32 l
f*
397.32 419.76 l
335.28 345.24 l
281.52 624.6 l
453 444.48 l
120.96 460.92 7.2 -2.64 re
138.6 480.24 l
380.16 376.56 7.2 -2.04 re
148.56 565.56 m
f*
190.2 154.8 l
121.572 570 114.96 576.559 114.96 584.64 c
172.68 262.08 l
367.44 256.92 m
169.92 267 l
f*
465.72 586.44 l
f*
441.6 529.2 l
290.16 307.92 l
1 i 1 J 1 j 0.96 w 10 M []0 d
1 g
251.04 234.36 l
275.52 302.52 0.36 -0.06 re
1.807 0 TD
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152.88 615.679 159.815 622.56 168.36 622.56 c
f*
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234 565.32 l
369.96 615.12 m
-0.005 Tc
182.04 146.4 m
0.044 Tw
177.48 248.28 6 -2.28 re
q
f*
160.2 409.32 l
408.36 555.12 l
171.24 535.92 l
117 300.96 0.48 -0.06 re
230.04 622.8 l
133.68 444.72 l
341.28 264.72 l
353.16 360.96 l
335.04 621.12 m
349.68 281.16 l
1 i 1 J 1 j 0.96 w 10 M []0 d
f*
s
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f*
164.64 437.64 l
117.558 236.16 109.44 244.278 109.44 254.28 c
f*
398.52 218.4 l
346.44 573.6 0.84 -0.06 re
164.88 214.8 l
365.64 424.68 l
177.48 265.44 l
194.52 204.48 m
1.807 0 TD
195.48 234.84 1.68 -0.06 re
f*
185.52 235.44 1.8 -0.06 re
336 248.88 l
488.28 563.28 l
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356.88 571.92 0.36 -0.06 re
243.6 604.2 l
349.44 610.92 l
192.48 456 l
178.92 566.16 l
S
381.36 233.64 l
f*
/F12 1 Tf
-3.012 -1.072 TD
-7.433 -1.087 TD
457.32 453.12 l
1 g
216.96 189.96 l
463.08 391.68 l
201.6 420.48 l
253.32 219.84 6 -3.72 re
f*
393.36 174.72 l
117.798 292.08 109.68 300.144 109.68 310.08 c
293.28 282.348 299.892 288.96 308.04 288.96 c
0 G
398.4 552.12 l
381.36 573.72 0.12 -0.06 re
380.28 431.4 l
170.76 544.08 l
160.32 408.36 l
323.16 625.32 l
290.4 226.8 1.56 -0.06 re
194.52 189.96 l
S
462.72 574.08 l
322.56 293.88 l
386.28 540.6 l
215.88 145.32 l
0.749 g
364.32 257.52 m
336.6 264.72 l
f*
335.16 148.2 l
424.2 547.68 l
333.12 575.28 l
387.24 507.36 l
155.04 266.16 l
135.48 272.28 l
164.88 673.32 6 -3.84 re
-3.521 -1.607 TD
180 302.4 1.08 -0.06 re
417.96 306.6 l
f*
182.04 301.32 0.48 -0.06 re
450.6 540.12 m
424.08 599.76 l
393.24 566.16 l
0.184 Tw
f*
f*
208.92 211.68 m
138.96 441.12 l
497.16 315.12 1.8 -0.06 re
300.96 558.72 l
286.56 407.76 l
204.24 189.96 m
f*
495.48 309.12 0.96 -0.06 re
352.8 225.72 1.56 -0.06 re
406.2 580.56 m
340.68 415.44 0.48 -0.06 re
162.48 257.28 1.56 -0.06 re
159.24 534.84 l
297.074 565.92 289.44 573.554 289.44 582.96 c
408.24 582.72 m
228 248.76 m
f*
278.16 577.49 271.87 571.2 264.12 571.2 c
212.52 416.52 0.36 -0.06 re
256.32 526.44 l
295.56 492.36 m
451.92 445.68 l
219.24 257.64 l
0 G
261.36 407.76 l
254.88 552.72 l
202.8 141.84 m
278.88 303.6 0.6 -0.06 re
415.56 553.92 0.84 -0.06 re
208.44 510.96 l
218.28 273.24 l
f*
423.6 551.64 l
445.08 389.52 m
S
319.56 292.92 l
315.36 357.96 l
355.08 171 l
164.16 437.64 l
f*
0.569 g
445.92 276.36 l
f*
f*
335.4 532.2 l
215.4 150.6 l
443.64 600.24 l
405.48 166.8 l
308.88 249.72 l
233.76 147 l
194.52 580.68 l
215.04 567.84 l
190.44 565.8 l
392.88 224.28 m
386.16 256.92 l
292.2 148.56 l
f*
f*
462.36 505.8 l
S
164.16 545.28 m
448.44 266.52 l
317.88 618 l
438.12 607.08 l
245.28 413.88 l
261.12 267.24 l
451.8 297.6 l
261.24 524.4 l
194.64 261.72 l
q
0 g
258.72 618.72 l
392.88 218.16 l
190.2 505.08 l
1 0.749 0.749 RG
304.56 560.64 m
419.16 530.76 l
297.12 581.28 l
418.8 174.36 l
223.2 440.52 0.36 -0.06 re
509.04 534.48 0.84 -0.06 re
190.92 263.28 l
164.16 502.32 l
Q
173.28 533.28 l
201.24 547.8 l
232.56 189.96 m
469.32 706.08 m
385.32 573 0.36 -0.06 re
f*
335.52 624.48 l
138.96 445.68 l
139.08 233.76 l
445.08 371.52 l
q
320.76 297.12 m
228.48 580.8 m
f*
310.44 152.16 l
178.92 566.16 l
f*
BT
451.68 298.44 l
319.68 585.96 m
408.72 302.76 0.6 -0.06 re
309 241.56 l
S
f*
164.88 256.92 m
363.6 624.6 l
179.52 410.64 l
266.16 155.4 m
S
0001320798 00000 n
q
335.52 345.24 l
BT
281.16 615.96 l
1 g
430.8 184.08 l
f*
397.68 572.16 0.48 -0.06 re
286.44 553.44 0.6 -0.06 re
1 i 1 J 1 j 0.96 w 10 M []0 d
Q
495.12 252.48 l
6.96 0 0 6.96 407.4 673.44 Tm
355.56 189.96 l
0.075 0.271 0.8 rg
509.04 426 0.84 -0.06 re
318.96 641.76 l
ET
355.8 165.24 l
Gene Therapy Human Diseases Targeted for Gene Therapy Vectors and Other Delivery Systems for Gene Therapy 30. 346.92 346.8 m
149.04 278.4 l
f*
372.12 166.68 m
410.04 566.16 l
190.2 552.96 l
394.56 437.64 l
418.32 182.28 l
445.08 306.84 l
333.24 571.68 l
113.4 301.32 0.48 -0.06 re
349.56 297.24 l
382.08 410.28 l
284.64 530.76 l
438.36 566.16 l
1 i 1 J 1 j 0.96 w 10 M []0 d
1 g
207.36 409.8 l
S
438.36 528.12 l
203.64 494.16 l
120.96 299.52 l
497.52 246 l
(106.02)Tj
0 G
[(definition. 189.72 553.44 l
f*
152.16 601.44 6 -7.68 re
f*
164.16 486.48 m
331.56 415.68 l
q
S
W n
157.68 580.8 l
f*
216.24 444.6 m
127.2 297.72 l
f*
f*
394.56 435.24 m
263.28 277.8 l
160.08 299.64 l
T*
185.76 382.8 m
251.28 409.56 l
259.32 565.32 l
382.8 598.92 l
240.6 610.2 l
164.88 552.84 l
169.32 268.32 l
287.16 226.2 1.68 -0.06 re
0.961 g
(2)Tj
374.16 279.48 l
263.76 629.88 l
160.8 410.4 l
0.047 0.169 0.506 rg
310.2 204.48 l
330.48 233.4 l
317.16 277.68 l
157.68 565.8 l
319.56 550.68 l
385.92 221.28 l
393.12 189.84 l
170.4 503.28 l
134.04 435.12 l
430.44 611.64 l
191.16 552.96 l
435.36 535.44 l
444 265.08 l
145.92 303.96 0.36 -0.06 re
226.2 223.44 l
f*
247.8 236.88 l
318.96 574.44 0.48 -0.06 re
201.72 493.2 l
120.96 452.88 l
211.32 248.76 l
228.48 146.28 l
254.52 235.44 l
509.52 451.44 0.96 -0.06 re
164.16 417.48 m
164.88 528.72 l
284.04 543.6 l
410.64 617.52 l
S
f*
203.04 422.52 l
241.08 544.68 m
f*
358.56 516.12 7.08 -6.36 re
385.32 266.28 l
223.44 566.28 l
255 552.72 l
365.64 450.72 l
286.32 438.48 0.36 -0.06 re
0 g
f*
394.56 416.76 l
f*
248.76 644.52 l
354.96 364.2 l
461.04 231.12 l
409.92 534.24 l
1 g
319.2 255.96 l
Q
372.12 166.68 l
475.44 263.4 l
196.2 505.08 l
170.88 211.56 l
266.64 151.56 l
215.4 589.92 m
147.6 283.2 l
448.32 534.84 l
515.16 258.12 l
215.4 626.64 l
f*
1 i 1 J 1 j 0.96 w 10 M []0 d
367.68 533.76 l
270 610.32 l
306.12 142.8 l
b*
162.6 257.04 1.56 -0.06 re
f*
396.24 573.72 0.36 -0.06 re
429.6 563.88 l
0.003 Tc
T*
W n
174.24 557.88 l
230.4 251.823 225.777 247.2 220.08 247.2 c
4.217 0 TD
269.4 344.64 l
262.2 265.92 l
406.2 173.64 l
203.76 435.24 l
342.36 617.52 l
S
b*
291.24 581.16 l
315.96 299.52 l
386.88 440.28 0.36 -0.06 re
f*
398.76 413.28 l
423.72 204.48 l
f*
446.16 459.72 l
290.16 299.64 l
323.16 231.12 l
f*
f*
q
f*
152.16 616.32 6 -3 re
f*
241.32 621.12 l
ET
353.28 441.96 1.32 -0.06 re
190.2 116.76 l
396.36 218.16 l
241.2 600.96 l
424.32 171.24 l
215.76 250.92 l
282.96 410.16 m
167.88 503.64 l
259.32 637.8 l
323.16 145.44 l
256.44 268.32 l
304.68 143.4 l
380.28 166.92 l
368.16 603.96 l
470.4 561.12 l
159.6 252.72 l
T*
418.56 543.72 l
152.16 565.44 l
227.52 267.96 l
219.96 580.68 l
445.08 325.92 l
[(. 438.12 581.16 l
0 Tc
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304.8 527.88 l
450.36 297.24 m
f*
350.28 216.6 l
107.4 344.88 l
Q
164.88 110.16 6 -5.28 re
202.56 447.84 l
406.92 415.08 0.48 -0.06 re
438 214.2 l
445.44 240.72 l
322.2 357.6 l
418.32 174.36 l
0 g
W n
200.4 531.6 l
424.2 543.48 l
f*
230.76 415.44 l
170.16 435.24 l
T*
412.8 246.165 405.381 238.8 396.24 238.8 c
432.96 413.76 l
264.48 360.48 m
322.92 145.8 l
0 Tw
290.16 358.44 l
348.36 606.96 l
164.16 542.28 m
444.12 513.24 l
197.04 547.56 l
190.2 637.8 l
398.88 218.16 l
246.6 263.28 l
484.56 392.52 l
405.48 212.88 l
14.4 225.36 582.48 -5.4 re
433.68 414.12 l
202.8 509.16 l
224.76 233.76 l
1 g
180 301.2 0.48 -0.06 re
(9,373,915)Tj
305.88 580.68 l
356.28 228 1.44 -0.06 re
272.04 189.6 l
f*
329.76 233.4 l
296.04 573.36 0.36 -0.06 re
367.68 165.12 l
405.72 546.48 l
0.001 Tc
452.28 269.4 l
1 g
170.76 545.64 l
f*
305.04 617.76 l
14.4 225.36 582.48 -5.4 re
349.8 345.24 l
f*
-3.012 -1.084 TD
248.28 240 l
f*
ET
225.36 418.68 l
384.96 246.48 l
f*
5.88 0 0 5.88 481.08 269.88 Tm
S
360.48 541.8 l
203.04 133.92 l
f*
250.8 545.4 l
127.56 408.48 l
f*
q
410.04 543.84 l
f*
160.56 425.64 l
228.12 624.12 l
340.56 631.8 m
330.72 524.64 l
400.32 425.16 l
1 g
269.28 572.52 0.36 -0.06 re
0.051 0.192 0.569 rg
209.16 426.96 l
0.065 Tw
257.76 580.68 l
S
483.6 552.36 0.84 -0.06 re
354.96 417.84 l
f*
277.44 211.68 m
1 i 1 J 1 j 0.96 w 10 M []0 d
215.4 143.4 l
(1)Tj
152.16 676.56 l
211.32 414.96 0.6 -0.06 re
f
f*
[(1953)-787(The structure of DNA is established to be a)]TJ
192.72 307.44 l
f*
420.48 573.36 0.48 -0.06 re
380.28 548.28 l
300.96 408 l
S
354.96 284.16 l
8.04 0 0 8.04 220.92 370.92 Tm
1 i 1 J 1 j 0.96 w 10 M []0 d
f*
190.2 135.72 6 -3 re
438.12 151.08 m
f*
481.08 633.72 l
(sickle-cell anemia. f*
380.88 409.68 l
q
(mRNA)Tj
128.16 297.12 m
198.24 435.24 m
419.28 174 l
f*
1 g
282.96 293.4 m
152.88 244.32 l
208.8 631.56 l
f*
f*
186.24 456.12 l
317.16 528.72 l
120.96 253.08 l
S
ET
185.28 412.56 l
419.52 411 l
207.24 189.96 l
387.24 303 l
221.28 625.92 l
378.96 288.48 l
345.464 242.88 339.12 249.17 339.12 256.92 c
117.6 126.72 l
f*
286.44 442.08 0.24 -0.06 re
1 g
f*
310.44 250.2 l
180.826 321.6 184.32 318.159 184.32 313.92 c
268.56 432.6 l
0.048 Tw
f*
315.24 407.64 m
164.88 125.52 l
272.16 189.48 l
(in non-living cellular extracts. 155.52 571.56 l
204.24 189.96 l
507.24 324.72 l
f*
f*
f*
306.06 753.6 m
293.4 428.4 l
423.72 223.8 l
448.92 551.88 0.48 -0.06 re
358.08 312.72 l
S
f*
f*
f*
573 44.824 567.896 39.72 561.6 39.72 c
0.067 0.243 0.725 rg
284.76 354.36 l
522 123.6 l
Q
204.24 204.48 l
127.2 304.32 l
229.56 566.16 l
188.16 297.24 l
451.68 409.8 l
284.4 238.68 l
423.12 532.2 l
329.16 547.92 l
555.84 101.16 l
164.88 140.52 l
f*
253.32 592.2 6 -1.8 re
278.52 630.36 l
305.04 580.56 l
496.56 314.4 0.24 -0.06 re
S
423.48 540.84 m
466.68 448.56 l
310.56 250.8 l
348.36 551.88 l
The scope of the Journal of Clinical Microbiology ® (JCM) includes the laboratory diagnosis of human and animal infections, the role of the laboratory in managing infectious diseases (including antimicrobial and diagnostic test stewardship), and the role of the laboratory in elucidating the epidemiology of infections. 0 g
407.16 219.36 l
q
440.64 413.04 0.48 -0.06 re
420 407.4 l
B*
263.76 207.36 l
522 346.44 l
316.44 225.12 l
f*
197.04 536.4 l
152.52 580.92 l
0 G
291.6 244.92 l
423.96 170.76 l
288.12 224.04 2.64 -0.06 re
318.72 624.36 l
154.44 542.88 l
T*
183.48 529.2 l
f*
470.04 414.24 0.36 -0.06 re
-0.308 -1.22 TD
f*
145.32 504.6 l
273.24 425.52 l
f*
Q
f*
261.96 435.24 l
329.76 594.48 6 -1.92 re
232.56 189.96 m
443.4 590.16 m
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